Herbal Spotlight
|
|
NEW INDICATION & DOSAGE
Gout flares—
Adults: 1.2 mg (2 tablets) P.O. at the first sign of gout flare, followed by 0.6 mg (1 tablet) 1 hour later. Maximum dose, 1.8 mg over a 1-hour period.
ADJUST-A-DOSE: If creatinine clearance is less than 30 ml/minute, repeat the dose no more than once every 2 weeks. For these patients requiring repeated courses, consider alternate therapy. For patients undergoing dialysis, the total recommended dose is a single dose of 0.6 mg (1 tablet); repeat the dose no more than once every 2 weeks. For severe hepatic impairment, no dosage adjustment is necessary, but the dose shouldn't be repeated more than once every 2 weeks.
Familial Mediterranean fever—
Adults: 1.2 mg to 2.4 mg P.O. daily in one or two divided doses. Increase as needed to control disease and as tolerated in increments of 0.3 mg/day to the maximum recommended daily dose, 2.4 mg. If intolerable adverse effects develop, the dose should be decreased in increments of 0.3 mg/day.
Adolescents 12 years and older: 1.2 mg to 2.4 mg daily, in one or two divided doses.
Children ages 6 to 12 years: 0.9 mg to 1.8 mg P.O. daily, in one or two divided doses.
Children ages 4 to 6 years: 0.3 mg to 1.8 mg P.O. daily, in one or two divided doses.
ADJUST-A-DOSE: If creatinine clearance is less than 30 ml/minute, initially give 0.3 mg P.O. daily; may increase dose as tolerated. For patients undergoing dialysis, initially give 0.3 mg P.O. daily. May increase as tolerated. For patients with severe hepatic impairment, consider a reduced dose.
|
colchicine