Herbal Spotlight
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 dexlansoprazole |
| Kapidex |
Pharmaceutical
company:
Takeda Pharmaceuticals North America, Inc.
www.kapidex.com |
Pharmacologic classification: proton pump inhibitor
Therapeutic classification: gastric acid suppressant
Pregnancy risk category: B
AVAILABLE FORMS
Capsules: 30 mg, 60 mg
INDICATIONS AND DOSAGES
Erosive esophagitis—
Adults: Initially, 60 mg P.O. once daily for up to 8 weeks; maintenance dose, 30 mg P.O. once daily for up to 8 months.
Symptomatic nonerosive gastroesophageal reflux disease (GERD)—
Adults: 30 mg P.O. once daily for 4 weeks.
ADJUST-A-DOSE: For patients with moderate hepatic impairment (Child-Pugh Class B), maximum dose is 30 mg P.O. daily.
CONTRAINDICATIONS AND CAUTIONS
Contraindicated in patients hypersensitive to the drug or its components.
Use cautiously with suspected gastric malignancy.
INTERACTIONS
Drug-drug.
Warfarin: May increase INR and the risk of bleeding. Monitor patient closely.
Atazanavir: May decrease atazanavir level. Avoid use together.
Drugs with pH-dependent absorption (ampicillin, digoxin, ketoconazole, iron): May decrease absorption of these drugs. Use together cautiously.
ADVERSE REACTIONS
CNS: abnormal dreams, altered taste, anxiety, seizures, depression, dizziness, fever, headaches, insomnia, memory impairment, paresthesias, psychomotor hyperactivity, tremor, trigeminal neuralgia.
CV: angina, arrhythmia, bradycardia, chest pain, deep vein thrombosis, edema, hypertension, myocardial infarction, palpitation, tachycardia.
EENT: ear pain, eye irritation, eye swelling, nasopharyngitis, sinusitis, tinnitus, vertigo.
GI: abdominal discomfort, abdominal tenderness, abnormal stools, altered gastric motility, anal discomfort, appetite changes, Barrett's esophagus, breath odor, cholelithiasis, colon or gastric polyps, constipation, diarrhea, dry mouth, dyspepsia, flatulence, hematemesis, hemorrhoids, irritable bowel syndrome, nausea, oral paresthesias, proctitis, rectal hemorrhage, vomiting.
GU: dysmenorrhea, dyspareunia, dysuria, menstrual disorder, micturition urgency, vulvovaginal infection.
Hematologic: anemia, lymphadenopathy.
Hepatic: biliary colic, hepatomegaly.
Musculoskeletal: arthralgia, arthritis, muscle cramps, musculoskeletal pain, myalgia.
Respiratory: aspiration, asthma, bronchitis, cough, sore throat, upper respiratory tract infection.
Skin: acne, dermatitis, erythema, pruritus, rash, urticaria.
Other: Candida infections, chills, goiter, hot flush, hypersensitivity, inflammation influenza, libido changes, viral infection, oral herpes.
Reactions may be common, uncommon, life-threatening,
or COMMON AND LIFE-THREATENING.
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